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One-pot synthesis and SAR study of cis-2,6-dialkyl-4-chloro-tetrahydropyrans.

Abstract：

:A series of cis-2,6-dialkyl-4-chloro-tetrahydropyrans were prepared by means of an iron(III)-catalyzed process. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, SW1573, and WiDr. The results show that the presence of bulky substituents favors the Prins cyclization leading to new products with better activity profile against all cell lines tested.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Miranda PO,León LG,Martín VS,Padrón JI,Padrón JM

doi

10.1016/j.bmcl.2006.03.064

subject

Has Abstract

pub_date

2006-06-15 00:00:00

pages

3135-8

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00363-5

journal_volume

16

pub_type

杂志文章

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