Abstract:
:A series of gibberellin based molecules were designed and synthesized. Gibberellin derivatives bearing two alpha,beta-unsaturated ketone units showed strong anticancer activities in MTT assay towards a number of human cancer cell lines including HT29, A549, HepG2 and MKN28. The most potent gibberellin derivative (compound 10, IC(50)=2.9 microM against HT29) inhibited completely the topoisomerase I activity at 8 microg/mL level.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Chen J,Sun Z,Zhang Y,Zeng X,Qing C,Liu J,Li L,Zhang Hdoi
10.1016/j.bmcl.2009.07.090subject
Has Abstractpub_date
2009-09-15 00:00:00pages
5496-9issue
18eissn
0960-894Xissn
1464-3405pii
S0960-894X(09)01024-5journal_volume
19pub_type
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