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Inhibition of human cytomegalovirus protease N(o) with monocyclic beta-lactams.

Abstract：

:Monocyclic beta-lactams have been identified as potent and selective inhibitors of the human cytomegalovirus protease (HCMV) N(o). Two series of these inhibitors are described, a peptidyl series of compounds and non-peptidic molecules featuring lower molecular weights. The SAR work that lead to the discovery of these inhibitors, together with their synthesis is also disclosed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Déziel R,Malenfant E

doi

10.1016/s0960-894x(98)00240-6

subject

Has Abstract

pub_date

1998-06-02 00:00:00

pages

1437-42

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960894X98002406

journal_volume

8

pub_type

杂志文章

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