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Structural measurements and cell line studies of the copper-PEG-Rifampicin complex against Mycobacterium tuberculosis.

Abstract：

:The bacterium responsible for tuberculosis is increasing its resistance to antibiotics resulting in new multidrug-resistant Mycobacterium tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). In this study, several analytical techniques including NMR, FT-ICR, MALDI-MS, LC-MS and UV/Vis are used to study the copper-Rifampicin-Polyethylene glycol (PEG-3350) complex. The copper (II) cation is a carrier for the antibiotic Rifampicin as well as nutrients for the bacterium. The NIH-NIAID cell line containing several Tb strains (including antibiotic resistant strains) is tested against seven copper-PEG-RIF complex variations.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Manning T,Mikula R,Wylie G,Phillips D,Jarvis J,Zhang F

doi

10.1016/j.bmcl.2014.12.053

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

451-8

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)01361-4

journal_volume

25

pub_type

杂志文章

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