The binding of cocaine to cyclodextrins.

Abstract:

:Cocaine binds into beta-cyclodextrin, but not detectably into alpha- or gamma-cyclodextrin, in water solution. NMR studies indicate the geometry of the complex, which is confirmed by molecular mechanics calculations and binding studies on cocaine analogues and cyclodextrin dimers.

journal_name

Bioorg Med Chem Lett

authors

Nesna N,Lou J,Breslow R

doi

10.1016/s0960-894x(00)00371-1

subject

Has Abstract

pub_date

2000-09-04 00:00:00

pages

1931-3

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960894X00003711

journal_volume

10

pub_type

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