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Synthesis and haemolytic activity of novel salts made of nicotine alkaloids and bile acids.

Abstract：

:A series of novel salts made of nicotine alkaloids and bile acids were synthesized and their haemolytic activity was examined in vitro using human erythrocytes. All compounds were characterized by spectroscopic methods. The novel salts show membrane-perturbing properties inducing the erythrocyte shape alterations and haemolysis in dose-dependent manner. Nicotine decreases the membrane interacting potential of bile acids in the novel compounds. The presence of sulfur or selenium atom in the nicotine molecule affects the haemolytic activity of its novel salts depending on the hydrophobicity of bile acids.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Jasiewicz B,Mrówczyńska L,Malczewska-Jaskóła K

doi

10.1016/j.bmcl.2014.01.005

subject

Has Abstract

pub_date

2014-02-15 00:00:00

pages

1104-7

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00024-9

journal_volume

24

pub_type

杂志文章

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