Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.

Abstract:

:Although thrombin has been extensively researched with many examples of potent and selective inhibitors, the key characteristics of oral bioavailability and long half-life have been elusive. We report here a novel series non-peptidic phenyl-based, highly potent, highly selective and orally bioavailable thrombin inhibitors using oxyguanidines as guanidine-mimetics.

journal_name

Bioorg Med Chem Lett

authors

Tomczuk B,Lu T,Soll RM,Fedde C,Wang A,Murphy L,Crysler C,Dasgupta M,Eisennagel S,Spurlino J,Bone R

doi

10.1016/s0960-894x(03)00125-2

subject

Has Abstract

pub_date

2003-04-17 00:00:00

pages

1495-8

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960894X03001252

journal_volume

13

pub_type

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