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New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes.

Abstract：

:A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Dhimitruka I,Eubank TD,Gross AC,Khramtsov VV

doi

10.1016/j.bmcl.2015.08.054

subject

Has Abstract

pub_date

2015-10-15 00:00:00

pages

4593-6

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)30006-8

journal_volume

25

pub_type

杂志文章

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