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Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.

Abstract：

:Natural inhibitors of fatty acid synthase (FAS) are emerging as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which compounds 7, 8, 9, 10, and 11 were isolated from this plant for the first time and compound 9 was a new natural product. These isolates possess strong inhibitory activity of FAS with the IC(50) values ranging from 1.24 to 91.07 μM. The study indicates that two types of natural products, xanthones and benzophenones, could be considered as promising FAS inhibitors.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Jiang HZ,Quan XF,Tian WX,Hu JM,Wang PC,Huang SZ,Cheng ZQ,Liang WJ,Zhou J,Ma XF,Zhao YX

doi

10.1016/j.bmcl.2010.08.061

subject

Has Abstract

pub_date

2010-10-15 00:00:00

pages

6045-7

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01184-4

journal_volume

20

pub_type

杂志文章

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