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An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction.

Abstract：

:Novel fused 1H-benzo[f]chromen-indole derivatives were synthesized regioselectivly in good to high yields by triethyl amine catalyzed condensation of 3-cyanoacetylindoles, β-naphthol and aryl aldehydes in methanol under ultrasounic irradiations and conventional conditions. The easy work-up of the products, rapidity, and mild reaction conditions are notable features of this protocol. The antibacterial activity of the selected products was examined. Some products showed promising activities.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Hossein nia R,Mamaghani M,Tabatabaeian K,Shirini F,Rassa M

doi

10.1016/j.bmcl.2012.07.059

subject

Has Abstract

pub_date

2012-09-15 00:00:00

pages

5956-60

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00935-3

journal_volume

22

pub_type

杂志文章

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