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Synthesis and inhibitory activity of ubiquinone-acetogenin hybrid inhibitor with bovine mitochondrial complex I.

Abstract：

:To elucidate the inhibitory action of acetogenins, the most potent inhibitors of mitochondrial complex I, we synthesized an acetogenin analogue which possesses a ubiquinone ring (i.e., the physiological substrate of complex I) in place of the alpha,beta-unsaturated gamma-lactone ring of natural acetogenins, and named it Q-acetogenin. Our results indicate that the gamma-lactone ring of acetogenins is completely substitutable with the ubiquinone ring. This fact is discussed in light of the inhibitory action of acetogenins.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yabunaka H,Abe M,Kenmochi A,Hamada T,Nishioka T,Miyoshi H

doi

10.1016/s0960-894x(03)00439-6

subject

Has Abstract

pub_date

2003-07-21 00:00:00

pages

2385-8

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960894X03004396

journal_volume

13

pub_type

杂志文章

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