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Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors.

Abstract：

:Cyclin-dependent kinase 5 (CDK5) is a serine-threonine protein kinase that plays a significant role in neuronal development. In association with p25, CDK5 abnormally phosphorylates a number of cellular targets involved in neurodegenerative disorders. Using active site homology and previous structure-activity relationships, a new series of potent CDK5 inhibitors was designed. This report describes the optimization of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kaller MR,Zhong W,Henley C,Magal E,Nguyen T,Powers D,Rzasa RM,Wang W,Xiong X,Norman MH

doi

10.1016/j.bmcl.2009.10.027

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

6591-4

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01428-0

journal_volume

19

pub_type

杂志文章

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