Abstract:
:DNA is a promising functional molecule to modify and design lipid membrane functions. In order to use DNA in a hydrophilic-hydrophobic interface including lipid membrane, we have developed an amphiphilic DNA having dodecyl phosphotriester linkages (dod-DNA). Herein, we report the binding of a series of amphiphilic dod-DNAs to the lipid bilayer membrane. Surface plasmon resonance (SPR) assay and fluorescent microscopy showed that dod-DNA having three dodecyl groups at each end strongly bound to lipid membrane due to the slow dissociation rate and the dod-DNA can be used as a linear template for molecular arrangement on the membrane surface.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Makishi S,Shibata T,Okazaki M,Dohno C,Nakatani Kdoi
10.1016/j.bmcl.2014.05.042subject
Has Abstractpub_date
2014-08-01 00:00:00pages
3578-81issue
15eissn
0960-894Xissn
1464-3405pii
S0960-894X(14)00542-3journal_volume
24pub_type
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