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Cyclohexanedione herbicides are inhibitors of rat heart acetyl-CoA carboxylase.

Abstract：

:Acetyl CoA carboxylase (ACC) catalyzes the carboxylation of acetyl CoA to form malonyl CoA. In skeletal muscle and heart, malonyl CoA functions to regulate lipid oxidation by inhibition of carnitine palmitoyltransferase-1, an enzyme which controls the entry of long chain fatty acids into mitochondria. We have found that several members of the cyclohexanedione class of herbicides are competitive inhibitors of rat heart ACC. These compounds constitute valuable reagents for drug development and the study of ACCbeta, a validated anti-obesity target.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Seng TW,Skillman TR,Yang N,Hammond C

doi

10.1016/s0960-894x(03)00664-4

subject

Has Abstract

pub_date

2003-10-06 00:00:00

pages

3237-42

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960894X03006644

journal_volume

13

pub_type

杂志文章

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