4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists.

Abstract:

:A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.

journal_name

Bioorg Med Chem Lett

authors

Cocuzza AJ,Hobbs FW,Arnold CR,Chidester DR,Yarem JA,Culp S,Fitzgerald L,Gilligan PJ

doi

10.1016/s0960-894x(99)00132-8

subject

Has Abstract

pub_date

1999-04-05 00:00:00

pages

1057-62

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(99)00132-8

journal_volume

9

pub_type

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