Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules.

Abstract:

:We sought to design dual pharmacology bronchodilators targeting both the M(3) muscarinic acetylcholine and beta-2 adrenergic (β(2)) receptors by applying our multivalent approach to drug discovery. Herein, we describe our initial discovery and the SAR of the first such compounds with matched potencies at both receptors.

journal_name

Bioorg Med Chem Lett

authors

Hughes AD,Chin KH,Dunham SL,Jasper JR,King KE,Lee TW,Mammen M,Martin J,Steinfeld T

doi

10.1016/j.bmcl.2011.01.043

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

1354-8

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)00066-7

journal_volume

21

pub_type

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