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Modulation of multidrug resistance in tumor cells by taxinine derivatives.

Abstract：

:Among a series of taxinine (1) and its designed derivatives (2-33), two taxoids (29 and 33) increased cellular accumulation of vincristine in multidrug-resistant tumor cells more potently than verapamil, while the activities of eight taxoids (11, 14-16, 22, and 30-32) were comparable with that of verapamil. These results reveal that some taxinine derivatives are good modifiers of multidrug resistance in tumor cells.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Hosoyama H,Shigemori H,Tomida A,Tsuruo T,Kobayashi J

doi

10.1016/s0960-894x(99)00009-8

subject

Has Abstract

pub_date

1999-02-08 00:00:00

pages

389-94

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960894X99000098

journal_volume

9

pub_type

杂志文章

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