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Novel quinolizidine salicylamide influenza fusion inhibitors.

Abstract：

:A novel series of quinolizidine salicylamides was synthesized as specific inhibitors of the H1 subtype of influenza A viruses. These inhibitors inhibit the pH-induced fusion process, thereby blocking viral entry into host cells. Compound 16 was the most active inhibitor in this series with an EC50 of 0.25 microg/mL in plaque reduction assay. The synthesis and the SAR of these compounds are discussed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yu KL,Ruediger E,Luo G,Cianci C,Danetz S,Tiley L,Trehan AK,Monkovic I,Pearce B,Martel A,Krystal M,Meanwell NA

doi

10.1016/s0960-894x(99)00361-3

subject

Has Abstract

pub_date

1999-08-02 00:00:00

pages

2177-80

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960894X99003613

journal_volume

9

pub_type

杂志文章

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