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Dicarboxylic acid esters as transdermal permeation enhancers: effects of chain number and geometric isomers.

Abstract：

:A series of transdermal permeation enhancers based on dicarboxylic acid esters was studied. Single-chain amphiphiles were markedly more effective than the double-chain ones. Monododecyl maleate, that is a cis derivative, was a more potent enhancer than its trans isomer, while the activity of succinates strongly depended on the donor vehicle. No difference between diastereoisomeric tartaric and meso-tartaric acid derivatives was found.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Novotný M,Hrabálek A,Janůsová B,Novotný J,Vávrová K

doi

10.1016/j.bmcl.2008.11.083

subject

Has Abstract

pub_date

2009-01-15 00:00:00

pages

344-7

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01467-4

journal_volume

19

pub_type

杂志文章

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