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Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide.

Abstract：

:There is a great urgency in developing a new generation of antibiotics and antimicrobial agents since the bacterial resistance to antibiotics have increased dramatically. A series of overlapped peptide fragments of Ixosin-B, an antimicrobial peptide with amino acid sequence of QLKVDLWGTRSGIQPEQHSSGKSDVRRWRSRY, was designed, synthesized and examined for their antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. A potent 11-mer peptide TSG-8-1, WWSYVRRWRSR-amide, was developed, which exhibited antimicrobial activity against E. coli and S. aureus while very little hemolytic activity in human erythrocytes was observed at high dose level. This peptide could be further modified for the development of a potent antimicrobial agent in the future.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wu YS,Liao ZJ,Wang KS,Lung FD

doi

10.1016/j.bmcl.2013.03.053

subject

Has Abstract

pub_date

2013-05-15 00:00:00

pages

2929-32

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)00381-8

journal_volume

23

pub_type

杂志文章

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