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N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists.

Abstract：

:A series of N-arylated phenylalanine derivatives has been synthesized and has been shown to be potent inhibitors of the integrin VLA-4. N-phenyl and N-heteroaryl derivatives with hydrogen bond acceptors in the meta position demonstrated low nanomolar activity against VLA-4.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Doherty GA,Kamenecka T,McCauley E,Van Riper G,Mumford RA,Tong S,Hagmann WK

doi

10.1016/s0960-894x(02)00009-4

subject

Has Abstract

pub_date

2002-03-11 00:00:00

pages

729-31

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960894X02000094

journal_volume

12

pub_type

杂志文章

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