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Potential α-glucosidase inhibitors from thermal transformation of (+)-catechin.

Abstract：

:Thermal transformation of the (+)-catechin (1) with heating processing afforded a new oxidation product, gambiriin D (2), along with catechin [6'-8]-catechin (3), and (+)-epicatechin (4). The structure of a new catechin dimer with C-C linkage was determined on the basis of spectroscopic data interpretation. The catechin dimers 2 and 3 exhibited significantly improved inhibitory activities against α-glucosidase, with IC50 values of 0.16±0.2 and 0.14±0.2μM, respectively, when compared to parent (+)-catechin. Kinetic analysis showed that the two effective compounds 2 and 3 have noncompetitive modes of action.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kim T,Choi HJ,Eom SH,Lee J,Kim TH

doi

10.1016/j.bmcl.2014.01.027

subject

Has Abstract

pub_date

2014-03-15 00:00:00

pages

1621-4

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00046-8

journal_volume

24

pub_type

杂志文章

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