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Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes.

Abstract：

:Paclitaxel (PTX) was complexed with beta-cyclodextrin (1), 2,6-dimethyl-beta-cyclodextrin (2) and 2,3,6-trimethyl-beta-cyclodextrin (3). PTX-CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement with molecular modeling analysis, which showed different PTX-CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Alcaro S,Ventura CA,Paolino D,Battaglia D,Ortuso F,Cattel L,Puglisi G,Fresta M

doi

10.1016/s0960-894x(02)00217-2

subject

Has Abstract

pub_date

2002-06-17 00:00:00

pages

1637-41

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960894X02002172

journal_volume

12

pub_type

杂志文章

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