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Synthesis of ketomethylene amino pseudopeptide analogues via reductive amination of glyoxals derived from alpha-amino acids.

Abstract：

:The reductive amination of an amino acid derived glyoxal, with the free amino group of a protected amino acid or oligopeptide fragment, has been developed as a simple and efficient method for the preparation of ketomethylene amino pseudo-oligopeptide isosteres Aa psi(COCH2NH)Aa. Trichlorosilane-DMF is the reagent of choice for the reduction.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Groarke M,Hartzoulakis B,McKervey MA,Walker B,Williams CH

doi

10.1016/s0960-894x(99)00637-x

subject

Has Abstract

pub_date

2000-01-17 00:00:00

pages

153-5

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(99)00637-X

journal_volume

10

pub_type

杂志文章

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