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Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression.

Abstract：

:A verbenachalcone derivative was synthesized and shown to protect N2a cells from caspase induction caused by serum starvation and to enhance the effect of NGF on neurite outgrowth in PC12 cells. As an initial investigation of the compound's mechanism(s) of action, we performed differential gene expression profiling in PC12 cells using oligonucleotide ( approximately 10,000 gene probes) microarrays. Gene expression patterns were compared in the presence of NGF (2 and 50 ng/mL) and NGF (2 ng/mL) plus the verbenachalcone derivative. Ten genes were significantly (2-fold; p0.05) up-regulated and seven genes were significantly down-regulated in the presence of the compound. These results were independently validated by quantitative real-time PCR for a subset of genes (cathepsin L, sigma-1 receptor and protein tyrosine phosphatase receptor type R). These genes or their protein products may represent useful therapeutic targets for treating neurodegeneration, such as Alzheimer's disease.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yeh LA,Padmanaban D,Ho P,Xing X,Rowley P,Morse LJ,Jensen RV,Cuny GD

doi

10.1016/j.bmcl.2004.12.001

subject

Has Abstract

pub_date

2005-02-15 00:00:00

pages

1193-6

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(04)01450-7

journal_volume

15

pub_type

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