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Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2.

Abstract：

:This manuscript concludes the Structure Activity Relationship (SAR) on the pyridazinone scaffold and identifies a compound with subnanomolar p38α activity and 24h coverage in the rat arthritis efficacy model.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Tynebor RM,Chen MH,Natarajan SR,O'Neill EA,Thompson JE,Fitzgerald CE,O'Keefe SJ,Doherty JB

doi

10.1016/j.bmcl.2012.07.035

subject

Has Abstract

pub_date

2012-09-15 00:00:00

pages

5979-83

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00911-0

journal_volume

22

pub_type

杂志文章

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