Abstract:
:Novel phenethylpyridone derivatives were identified as potent human melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. A search for surrogates for the 4-(2-aminoethoxy)phenyl moiety of 1 resulted in discovery of 2-[4-(aminomethyl)phenyl]ethyl substructure as in 6a. Successive optimization of the right-hand moiety led to the identification of a number of potent derivatives.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Ando M,Sekino E,Haga Y,Moriya M,Ito M,Ito J,Iwaasa H,Ishihara A,Kanatani A,Ohtake Ndoi
10.1016/j.bmcl.2009.07.023subject
Has Abstractpub_date
2009-09-01 00:00:00pages
5186-90issue
17eissn
0960-894Xissn
1464-3405pii
S0960-894X(09)00968-8journal_volume
19pub_type
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