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Neuroprotective effects of kobophenol A against the withdrawal of tropic support, nitrosative stress, and mitochondrial damage in SH-SY5Y neuroblastoma cells.

Abstract：

:This study examined the neuroprotective effects of kobophenol A (kob A), oligomeric stillbene, and a resveratrol tetramer. Neuronal death induced by the withdrawal of tropic support was ameliorated by kob A. The protective effect of kob A against nitrosative/oxidative or mitochondrial damages resulted in the inhibition of the ROS, intracellular calcium ion level, and mitochondrial transmembrane potential changes on SH-SY5Y cells.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Lee SR,Kwak JH,Kim HJ,Pyo S

doi

10.1016/j.bmcl.2007.01.078

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

1879-82

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00138-2

journal_volume

17

pub_type

杂志文章

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