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Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope.

Abstract：

:Group A streptococcus is a Gram-positive bacteria that causes a range of infectious diseases. Targeting the bacteria, a new self-adjuvanting vaccine candidate, incorporating a carbohydrate carrier and an amino acid-based adjuvant, was synthesised utilising carbohydrate chemistry and solid-phase peptide synthesis procedures. Characterisation of the candidate was achieved using reverse-phase HPLC and electrospray ionisation mass spectrometry. The successful synthesis and characterisation of the vaccine candidate may contribute to the discovery of a therapeutically and clinically viable vaccine against group A streptococcus.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Simerska P,Lu H,Toth I

doi

10.1016/j.bmcl.2008.12.013

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

821-4

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01517-5

journal_volume

19

pub_type

杂志文章

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