Abstract:
:This work describes the application of thermophilic microorganisms for obtaining 6-halogenated purine nucleosides. Biosynthesis of 6-chloropurine-2'-deoxyriboside and 6-chloropurine riboside was achieved by Geobacillus stearothermophilus CECT 43 with a conversion of 90% and 68%, respectively. Furthermore, the selected microorganism was satisfactorily stabilized by immobilization in an agarose matrix. This biocatalyst can be reused at least 70 times without significant loss of activity, obtaining 379mg/L of 6-chloropurine-2'-deoxyriboside. The obtained compounds can be used as antiviral agents.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Rivero CW,De Benedetti EC,Sambeth JE,Lozano ME,Trelles JAdoi
10.1016/j.bmcl.2012.08.045subject
Has Abstractpub_date
2012-10-01 00:00:00pages
6059-62issue
19eissn
0960-894Xissn
1464-3405pii
S0960-894X(12)01045-1journal_volume
22pub_type
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