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Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes.

Abstract：

:Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H(2)O(2)/TFE in presence of MeReO(3) as a catalyst. All of the synthesized compounds were characterized spectroscopically, and evaluated for cytotoxicity, and antimalarial activity. Several of these tetraoxanes exhibited in vitro antimalarial activity without showing any cytotoxicity. Thermal stability of these compounds was studied by differential scanning calorimetry.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Atheaya H,Khan SI,Mamgain R,Rawat DS

doi

10.1016/j.bmcl.2007.12.069

subject

Has Abstract

pub_date

2008-02-15 00:00:00

pages

1446-9

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)01526-0

journal_volume

18

pub_type

杂志文章

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