Abstract:
:An efficient and simple polymer-assisted approach has been developed to biotinylate multifunctional compounds bearing an amino functionality. Biotin was immobilized on aminomethylated polystyrene via the Kenner safety catch linker, activated and subsequently transferred to the amino function of the target compounds chemoselectively, thus avoiding protecting group operations. This approach holds potential for the introduction of spacer-modified biotin derivatives.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Golisade A,Herforth C,Wieking K,Kunick C,Link Adoi
10.1016/s0960-894x(01)00296-7subject
Has Abstractpub_date
2001-07-09 00:00:00pages
1783-6issue
13eissn
0960-894Xissn
1464-3405pii
S0960894X01002967journal_volume
11pub_type
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journal_title:Bioorganic & medicinal chemistry letters
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