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Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2.

Abstract：

:The structure-based design, synthesis, and anticancer activity of novel inhibitors of protein kinase CK2 are described. Using pyrazolo[1,5-a][1,3,5]triazine as the core scaffold, a structure-guided series of modifications provided pM inhibitors with microM-level cytotoxic activity in cell-based assays with prostate and colon cancer cell lines.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Nie Z,Perretta C,Erickson P,Margosiak S,Almassy R,Lu J,Averill A,Yager KM,Chu S

doi

10.1016/j.bmcl.2007.05.041

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

4191-5

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00607-5

journal_volume

17

pub_type

杂志文章

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