Synthesis of pyrazole peptidomimetics and their inhibition against A549 lung cancer cells.

Abstract:

:A series of novel pyrazole peptidomimetics was synthesized from 3-aryl-1-arylmethyl-1H-pyrazole-5-carboxylic acid and amino acid ester. Structures of the compounds were characterized by means of IR, (1)H NMR and mass spectroscopy. Compounds 5e and 5k suppress effectively the growth of A549 lung cancer cells. Preliminary research on the mechanism of action showed that the inhibition might perform through combination of apoptosis, autophagy and cell cycle arrest.

journal_name

Bioorg Med Chem Lett

authors

Liu YR,Luo JZ,Duan PP,Shao J,Zhao BX,Miao JY

doi

10.1016/j.bmcl.2012.09.032

subject

Has Abstract

pub_date

2012-11-15 00:00:00

pages

6882-7

issue

22

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)01178-X

journal_volume

22

pub_type

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