Abstract:
:A short route to pyrimidine locked nucleosides has been developed for their incorporation in triplex forming oligonucleotides (TFO). Compared to oligonucleotides built with standard nucleosides, the modified TFOs containing 3'-endo blocked residues formed, with their corresponding DNA duplexes, more stable triple helix systems, an effect which might be ascribed to the 3'-endo pucker of the modified nucleoside residues.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Savy P,Benhida R,Fourrey JL,Maurisse R,Sun JSdoi
10.1016/s0960-894x(00)00434-0subject
Has Abstractpub_date
2000-10-16 00:00:00pages
2287-9issue
20eissn
0960-894Xissn
1464-3405pii
S0960-894X(00)00434-0journal_volume
10pub_type
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