Abstract:
:NaIO4 oxidation of allosamidin (1), a strong inhibitor of family 18 chitinases, followed by a coupling with Biotin Hydrazide afforded its mono- and dibiotinylated derivatives, 4 and 6. Reduction of 4 by NaBH4 afforded its reduced form 5. Each of these three biotinylated derivatives maintained strong chitinase inhibitory activity. Especially, 6 inhibited a Trichoderma chitinase as strongly as 1.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Sakuda S,Sakurada Mdoi
10.1016/S0960-894X(98)00542-3subject
Has Abstractpub_date
1998-11-03 00:00:00pages
2987-90issue
21eissn
0960-894Xissn
1464-3405pii
S0960-894X(98)00542-3journal_volume
8pub_type
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