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Essential structural factors of acetogenins, potent inhibitors of mitochondrial complex I.

Abstract：

:To elucidate the role of the hydrophobic alkyl tail of acetogenins in the inhibitory action, we synthesized an acetogenin derivative possessing the shortest tail (i.e., methyl group) and examined its inhibitory activity against bovine heart mitochondrial complex I. Our results indicated that the alkyl tail, which is one of the common structural features of natural acetogenins, is not an essential structural factor required for the potent inhibition.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Motoyama T,Yabunaka H,Miyoshi H

doi

10.1016/s0960-894x(02)00374-8

subject

Has Abstract

pub_date

2002-08-19 00:00:00

pages

2089-92

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960894X02003748

journal_volume

12

pub_type

杂志文章

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