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Chemical constituents from the fruit of Gardenia jasminoides and their inhibitory effects on nitric oxide production.

Abstract：

:Three new iridoid glycosides, 6"-O-trans-caffeoylgenipin gentiobioside (1), genipin 1-O-β-D-apiofuranosyl (1→6)-β-D-glucopyranoside (2), genipin 1-O-α-D-xylopyranosyl (1→6)-β-D-glucopyranoside (3), three new monocyclic monoterpenoids, jasminoside R (4), jasminoside S (5), jasminoside T (6), together with nine known iridoid glycosides (7-15) and three crocetin glycosides (16-18), were isolated from the fruit of Gardenia jasminoides. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Inhibitory effects of the isolated compounds on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated. Compounds 8 and 18 showed strong inhibitory activity on NO production with IC(50) values of 11.14±0.67 and 5.99±0.54 μM, respectively.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Peng K,Yang L,Zhao S,Chen L,Zhao F,Qiu F

doi

10.1016/j.bmcl.2012.11.099

subject

Has Abstract

pub_date

2013-02-15 00:00:00

pages

1127-31

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)01551-X

journal_volume

23

pub_type

杂志文章

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