当前位置： SCI文献检索 > BIOORGANIC & MEDICINAL CHEMISTRY LETTERS期刊下所有文献 > Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha.

Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha.

Abstract：

:Optically active phenylpropanoic acid derivatives [(S)-5, and (R)-5] were prepared, and their affinities for peroxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma were evaluated. Binding assay and cell-based reporter assay indicated that the activity of these compounds is enantio-dependent, and resides exclusively on the (S)-isomer.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Miyachi H,Nomura M,Tanase T,Suzuki M,Murakami K,Awano K

doi

10.1016/s0960-894x(01)00732-6

subject

Has Abstract

pub_date

2002-02-11 00:00:00

pages

333-5

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960894X01007326

journal_volume

12

pub_type

杂志文章

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