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The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

Abstract：

:Aryl hydroxylamine derivatives have been synthesised that are some of the most potent inhibitors of hCMV protease prepared to date (IC50 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Smith DG,Gribble AD,Haigh D,Ife RJ,Lavery P,Skett P,Slingsby BP,Stacey R,Ward RW,West A

doi

10.1016/s0960-894x(99)00539-9

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

3137-42

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960894X99005399

journal_volume

9

pub_type

杂志文章

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