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Carbazolothiophene-2-carboxylic acid derivatives as endothelin receptor antagonists.

Abstract：

:The SmI(2)-promoted three-component coupling reaction of thiophene-2-carboxylate, indole-2-carbaldehyde and acetophenone provides an expedient route to a series of tetracyclic carbazolothiophene compounds bearing the indole and thiophene rings. Among these samples, 9-benzyl-4-methyl-4-(4-hydroxyphenyl)-10-oxo-4,10-dihydrocarbazolo[2,3-b]thiophene-2-carboxylic acid (18) shows the most potent inhibition against the endothelin-1 induced increase of intracellular calcium ion concentration.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Babu G,Yu HM,Yang SM,Fang JM

doi

10.1016/j.bmcl.2003.12.067

subject

Has Abstract

pub_date

2004-03-08 00:00:00

pages

1129-32

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960894X03013714

journal_volume

14

pub_type

杂志文章

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