Synthesis of betulinic acid derivatives with activity against human melanoma.

Abstract:

:Betulinic acid has been modified at C-3, C-20, and C-28 positions and the toxicity of the derivatives has been evaluated against cultured human melanoma (MEL-2) and human epidermoid carcinoma of the mouth (KB) cell lines. This preliminary investigation demonstrates that simple modifications of the parent structure of betulinic acid can produce potentially important derivatives, which may be developed as antitumor drugs.

journal_name

Bioorg Med Chem Lett

authors

Kim DS,Pezzuto JM,Pisha E

doi

10.1016/s0960-894x(98)00295-9

subject

Has Abstract

pub_date

1998-07-07 00:00:00

pages

1707-12

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960894X98002959

journal_volume

8

pub_type

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