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Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors.

Abstract：

:The synthesis of amidinoaryloxy 9-benzyl-8-methyl-9H-purine, 7,8-dihydropteridine-6(5H)-one and 5,7-dihydropyrimido[4,5-b][1,4]oxazine-6-one inhibitors of Factor Xa is described. These compounds show nanomolar potency against FXa and maintain high selectivity over thrombin and trypsin.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Buckman BO,Mohan R,Koovakkat S,Liang A,Trinh L,Morrissey MM

doi

10.1016/s0960-894x(98)00386-2

subject

Has Abstract

pub_date

1998-08-18 00:00:00

pages

2235-40

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960894X98003862

journal_volume

8

pub_type

杂志文章

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