Abstract：
:Quinolizidinyl derivatives of the tricyclic systems characterizing pirenzepine and nuvenzepine, were prepared and tested as ligands for muscarinic M1, M2 and M3 receptors; 5,11-dihydro-11-[(S-lupinyl)-thioacetyl]-6H-pyrido[2,3-b][1, 4]benzodiazepin-6-one exhibited IC50 = 10 nM for M1 and 760 nM for both M2 and M3 subtypes. During the synthesis some interesting side compounds were isolated and characterized.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Novelli F,Sparatore A,Tasso B,Sparatore Fdoi
10.1016/s0960-894x(99)00528-4subject
Has Abstractpub_date
1999-10-18 00:00:00pages
3031-4issue
20eissn
0960-894Xissn
1464-3405pii
S0960894X99005284journal_volume
9pub_type
杂志文章abstract：:A new method for the synthesis of 2'-O-methyl-2-thiouridine (s2Um) found in thermophilic bacterial tRNA was developed. Structural properties of s2Um and s2Um(p)U were studied by using 1H NMR spectroscopy. A modified nonaribonucleotide (RNA*: 5'-CGUUs2UmUUGC-3') was synthesized to study the base-recognition ability of ...
journal_title：Bioorganic & medicinal chemistry letters
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journal_title：Bioorganic & medicinal chemistry letters
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journal_title：Bioorganic & medicinal chemistry letters
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journal_title：Bioorganic & medicinal chemistry letters
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doi：10.1016/j.bmcl.2010.04.066
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journal_title：Bioorganic & medicinal chemistry letters
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journal_title：Bioorganic & medicinal chemistry letters
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更新日期：2005-06-02 00:00:00
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journal_title：Bioorganic & medicinal chemistry letters
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journal_title：Bioorganic & medicinal chemistry letters
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更新日期：2010-10-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry letters
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更新日期：2017-02-01 00:00:00
abstract：:Two thermostable α-carbonic anhydrases (α-CAs) isolated from thermophilic Sulfurihydrogenibium spp., namely SspCA (from S. yellowstonensis) and SazCA (from S. azorense), were shown in a previous work to possess interesting complementary properties. SspCA was shown to have an exceptional thermal stability, whereas SazC...
journal_title：Bioorganic & medicinal chemistry letters
pub_type： 杂志文章
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更新日期：2015-05-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry letters
pub_type： 杂志文章
doi：10.1016/j.bmcl.2019.01.031
更新日期：2019-03-01 00:00:00
abstract：:A series of cysteine diazomethyl- and chloromethyl ketone derivatives has been synthesized and evaluated against human B-lineage (Nalm-6) and T-lineage (Molt-3) acute lymphoblastic leukemia cell lines. The chloromethyl ketone compounds showed potent cytotoxicity against these cell lines, with IC50 values in the low mi...
journal_title：Bioorganic & medicinal chemistry letters
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journal_title：Bioorganic & medicinal chemistry letters
pub_type： 杂志文章
doi：10.1016/j.bmcl.2012.08.016
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journal_title：Bioorganic & medicinal chemistry letters
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journal_title：Bioorganic & medicinal chemistry letters
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journal_title：Bioorganic & medicinal chemistry letters
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journal_title：Bioorganic & medicinal chemistry letters
pub_type： 杂志文章
doi：10.1016/j.bmcl.2009.05.017
更新日期：2009-07-01 00:00:00
abstract：:A series of novel amino acid ester derivatives of 2,3-substituted isoindolinones was synthesized and evaluated for p53-mediated apoptotic activity. The rationale for augmentation of the target activity of 2,3-substituted isoindolinones was based on the introduction of new fragments in the structure of the inhibitor th...
journal_title：Bioorganic & medicinal chemistry letters
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更新日期：2016-02-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry letters
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更新日期：2005-05-16 00:00:00
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journal_title：Bioorganic & medicinal chemistry letters
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更新日期：2003-12-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry letters
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更新日期：2014-11-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry letters
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journal_title：Bioorganic & medicinal chemistry letters
pub_type： 杂志文章
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更新日期：2001-11-19 00:00:00
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journal_title：Bioorganic & medicinal chemistry letters
pub_type： 杂志文章
doi：10.1016/s0960-894x(98)00647-7
更新日期：1998-12-15 00:00:00
abstract：:Bcl homologs prominently contribute to apoptotic resistance in cancer cells and serve as molecular targets in treatment of various cancers. Herein, we report the synthesis of biphenyl-adamantane derivatives by a ligand free palladium on carbon based Suzuki reaction using diisopropylamine as a base for the coupling of ...
journal_title：Bioorganic & medicinal chemistry letters
pub_type： 杂志文章
doi：10.1016/j.bmcl.2015.12.026
更新日期：2016-02-01 00:00:00
abstract：:Halopemide, which was identified by HTS to inhibit phospholipase D2 (PLD2), provided the basis for an exploratory effort to identify potent inhibitors of PLD2 for use as inflammatory mediators. Parallel synthesis and purification were utilized to rapidly identify orally available amide analogs derived from indole 2-ca...
journal_title：Bioorganic & medicinal chemistry letters
pub_type： 杂志文章
doi：10.1016/j.bmcl.2007.01.059
更新日期：2007-04-15 00:00:00
