Abstract:
:The structures of the uracil and thiouracils were examined using NMR spectroscopy and crystal structure data when available. The relationships between the extent of polarization and the C5-C6 bond length as well as the H5-H6 coupling constants were probed. It was found that the bond length and coupling constants correlate well with the proton affinities at the carbonyl or thiocarbonyl groups at C4 but not C2. The possible implication in the tighter binding of thiouracil based nucleotides to orotidine-5'-monophosphate decarboxylase was discussed.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Huang S,Gronert S,Wu Wdoi
10.1016/j.bmcl.2011.08.109subject
Has Abstractpub_date
2011-11-01 00:00:00pages
6341-2issue
21eissn
0960-894Xissn
1464-3405pii
S0960-894X(11)01208-Xjournal_volume
21pub_type
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