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Cyclopentadienyltricarbonylrheniumbenzazepines: synthesis and binding affinity.

Abstract：

:Analogues of the benzazepine dopamine D1 receptor antagonist SCH-23390 incorporating the cyclo-pentadienyltricarbonyl-rhenium (CPTR) moiety were synthesized and evaluated pharmacologically. The CPTR derivatives retained affinity (0.3-2.9 nM) and D1 selectivity of the parent compound, supporting their use as neuropharmacological surrogates for 99mTc-labeled SPECT radiopharmaceuticals.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Tamagnan G,Baldwin RM,Kula NS,Baldessarini RJ,Innis RB

doi

10.1016/s0960-894x(00)00185-2

subject

Has Abstract

pub_date

2000-05-15 00:00:00

pages

1113-5

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(00)00185-2

journal_volume

10

pub_type

杂志文章

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