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Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui.

Abstract：

:As part of our ongoing search for anti-inflammatory compounds from higher plants, we isolated and elucidated two new diterpenoid glycosides, kansuingol A (1) and kansuingol B (2), from the roots of Euphorbia kansui. These structures were elucidated by extensive spectroscopic methods such as NMR and MS. Compounds were assessed for their IL-6 production inhibitory activity in PMA + A23187-stimulated HMC-1 cells. As a result, compounds 1 and 2 exerted inhibitory activities in the production of IL-6 with IC50 values of 2.96, and 1.94 μM, respectively. Further, kansuingol A (1) decreased mRNA expressions of TNF-α and IL-6.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kim YM,Ahn J,Chae HS,Choi YH,Kim J,Chin YW

doi

10.1016/j.bmcl.2018.02.050

subject

Has Abstract

pub_date

2018-04-15 00:00:00

pages

1207-1210

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(18)30154-9

journal_volume

28

pub_type

杂志文章

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