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Pyrazole NNRTIs 1: design and initial optimisation of a novel template.

Abstract：

:The design and synthesis of a novel series of non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on a pyrazole template is described. These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Mowbray CE,Burt C,Corbau R,Perros M,Tran I,Stupple PA,Webster R,Wood A

doi

10.1016/j.bmcl.2009.08.039

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

5599-602

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01175-5

journal_volume

19

pub_type

杂志文章

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