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N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents.

Abstract：

:The synthesis, anti-Pneumocystis carinii activity and DNA binding properties of eight new N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines are reported. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 microM concentrations.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Huang TL,Tao B,Quarshie Y,Queener SF,Donkor IO

doi

10.1016/s0960-894x(01)00541-8

subject

Has Abstract

pub_date

2001-10-22 00:00:00

pages

2679-81

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960894X01005418

journal_volume

11

pub_type

杂志文章

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