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The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa.

Abstract：

:Factor Xa, a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel anti-thrombotic agents. Here we describe the development of phenylglycine containing benzamidine carboxamides as novel, potent and selective inhibitors of factor Xa.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Jones SD,Liebeschuetz JW,Morgan PJ,Murray CW,Rimmer AD,Roscoe JM,Waszkowycz B,Welsh PM,Wylie WA,Young SC,Martin H,Mahler J,Brady L,Wilkinson K

doi

10.1016/s0960-894x(01)00042-7

subject

Has Abstract

pub_date

2001-03-12 00:00:00

pages

733-6

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960894X01000427

journal_volume

11

pub_type

杂志文章

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